ISSN 0914-4935

Sensors and Materials
is an international peer-reviewed open access journal to provide a forum for researchers working in multidisciplinary fields of sensing technology.
Sensors and Materials
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Hematocrit-insensitive Absolute Blood Flow Rate Measurement in 0.5-mm-diameter Flow Channel using MEMS-based Laser Doppler Velocimeter with Signal Modification for Detecting Beat Frequency from Broad Power Spectrum

Nobutomo Morita, Wataru Iwasaki, Hirofumi Nogami, Fumiya Nakashima, Eiji Higurashi, and Renshi Sawada

(Received May 28, 2018; Accepted October 3, 2018)

Keywords: MEMS, LDV, frequency weighting, peak detection, blood flow

We applied our millimeter-scale laser Doppler velocimeter (µ-LDV) as an absolute blood flow rate sensor in a thin tube (0.5 mm inner diameter) for precise control of the blood flow rate. We proposed a sequence of signal processing, frequency weighting modification and peak detection, and succeeded in the detection of the beat signal induced by flow at the center of the tube. Flow rates of 20,40,and 60% hematocrit (volume percentage of red blood cell in blood) were measured. The error ranges with respect to the hematocrit change were 14.2% for 58.9 µl/min, 5.1% for 235.6 µl/min, and 3.6% for 471.1 µl/min (corresponding maximum flow velocity of 80 mm/s), whereas the error ranges determined by laser Doppler flowmetry (LDF) calculation, which is generally used for blood flow measurement by the laser Doppler effect, were 89.2, 42.7, and 19.5%, respectively. The results show the potential application of µ-LDV as an integrable absolute blood flow rate sensor on a microchannel such as a thin tube and µ-TAS (micro-total analysis system) for a wide hematocrit range.

Corresponding author: Nobutomo Morita




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