Published: June 21, 2017
Biocompatibility Tests and Adhesion Improvements for Hydrogen-Free Amorphous Carbon for Blood-Contacting Medical Devices [PDF]
Yuya Yamato, Shunto Maegawa, Terumitsu Hasebe, Kenta Bito, Tomohiro Matsumoto, Takahiko Mine, Toshihiko Hayashi, Asushi Hotta, and Tetsuya Suzuki
(Received January 12, 2016; Accepted May 9, 2017)
Keywords: amorphous carbon, biomaterial, adhesive properties, biocompatibility
The hydrogenated amorphous carbon (a-C:H) film has been known as a coating material that imparts improved biocompatibility to base materials and has been used for many clinical applications. Recent studies have revealed that hydrogen-free amorphous carbon (H-free a-C) on stainless steel (SUS) has beneficial antibacterial properties, which allow avoidance of the risk of bacterial infection. In our study, to evaluate the biocompatibility of H-free a-C itself for blood-contacting devices, we investigated not only the ability to grow bacteria but also platelet aggregation on the surfaces of H-free a-C. Moreover, to apply H-free a-C to polytetrafluoroethylene (PTFE), we evaluated the adhesive properties of H-free a-C deposited after Ar or O2 plasma pre-treatment and fluorine-incorporated a-C:H (a-C:H:F) interlayer deposition. Antibacterial tests and antithrombogenic tests indicated that H-free a-C coating reduced bacterial adhesion and platelet activation in comparison with a-C:H coating. The adhesive strength of plasma-treated Ar and the interlayer deposited PTFE was five times larger than those of untreated PTFE from film adhesion tests. These results indicated that the pre-treated PTFE coated with H-free a-C is a promising candidate biomaterial for medical devices.
Corresponding author: Terumitsu Hasebe
Cite this article
Yuya Yamato, Shunto Maegawa, Terumitsu Hasebe, Kenta Bito, Tomohiro Matsumoto, Takahiko Mine, Toshihiko Hayashi, Asushi Hotta, and Tetsuya Suzuki, Biocompatibility Tests and Adhesion Improvements for Hydrogen-Free Amorphous Carbon for Blood-Contacting Medical Devices, Sens. Mater., Vol. 29, No. 6, 2017, p. 843-854.