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Vol. 34, No. 8(3), S&M3042

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Vol. 32, No. 8(2), S&M2292

Print: ISSN 0914-4935
Online: ISSN 2435-0869
Sensors and Materials
is an international peer-reviewed open access journal to provide a forum for researchers working in multidisciplinary fields of sensing technology.
Sensors and Materials
is covered by Science Citation Index Expanded (Clarivate Analytics), Scopus (Elsevier), and other databases.

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Sensors and Materials, Volume 24, Number 4 (2012)
Copyright(C) MYU K.K.
pp. 181-187
S&M878 Research Paper of Special Issue
https://doi.org/10.18494/SAM.2012.822
Published: May 14, 2012

Clinical Trial of Chronic Implantation of Suprachoroidal-Transretinal Stimulation System for Retinal Prosthesis [PDF]

Takashi Fujikado, Motohiro Kamei, Hirokazu Sakaguchi, Hiroyuki Kanda, Takeshi Morimoto, Yasushi Ikuno, Kentaro Nishida, Haruhiko Kishima, Tomoyuki Maruo, Hajime Sawai, Tomomitsu Miyoshi, Koji Osawa and Motoki Ozawa

(Received December 9, 2011; Accepted January 30, 2012)

Keywords: retinal prosthesis, retinitis pigmentosa, artificial vision, clinical trial, suprachoroidal-transretinal stimulation

Retinal prosthesis is an implantable medical device to reconstruct the sense of sight for blind individuals. We have been developing a new type of retinal prosthesis called suprachoroidal-transretinal stimulation (STS), whereby an electrode array is not attached to the retina directly. To evaluate the feasibility and safety of the retinal prosthesis using STS, a clinical trial was performed. We have developed an internal device for chronic implantation. It consists of a 49-channel electrode array that has 9 active electrodes. The retinal prosthesis was implanted in two patients with advanced retinitis pigmentosa (RP). Follow-up periods after implantation were five (Pt 1) and seven (Pt 2) weeks. No significant adverse event was observed in either patient after the surgical procedures. A functional test revealed that the detection or discrimination of objects was possible using the device, and a pulse frequency of around 20 Hz is the most effective in evoking phosphene. These clinical examinations showed that the retinal prosthesis with the STS system is safe and feasible for artificial vision.

Corresponding author: Takashi Fujikado


Cite this article
Takashi Fujikado, Motohiro Kamei, Hirokazu Sakaguchi, Hiroyuki Kanda, Takeshi Morimoto, Yasushi Ikuno, Kentaro Nishida, Haruhiko Kishima, Tomoyuki Maruo, Hajime Sawai, Tomomitsu Miyoshi, Koji Osawa and Motoki Ozawa, Clinical Trial of Chronic Implantation of Suprachoroidal-Transretinal Stimulation System for Retinal Prosthesis, Sens. Mater., Vol. 24, No. 4, 2012, p. 181-187.



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