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Vol. 32, No. 8(2), S&M2292

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ISSN (online) 2435-0869
Sensors and Materials
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Sensors and Materials, Volume 33, Number 1(2) (2021)
Copyright(C) MYU K.K.
pp. 223-232
S&M2448 Technical Paper of Special Issue
https://doi.org/10.18494/SAM.2021.3069
Published: January 22, 2021

Lab on a Tip: Atomic Force Microscopy as a Versatile Analytical Tool for Nano-bioscience [PDF]

Evan Angelo Quimada Mondarte, Hiroyuki Tahara, Kasinan Suthiwanich, Subin Song, Fan Wang, and Tomohiro Hayashi

(Received September 3, 2020; Accepted December 3, 2020)

Keywords: scanning probe microscopy, atomic force microscopy, single-molecule force spectroscopy, surface force

Scanning probe microscopy (SPM) is a powerful method for visualizing the structure of materials at the nanoscale. In particular, atomic force microscopy (AFM) has become one of the most used analytical tools in various fields such as physics, chemistry, and biology. Here, we introduce representative works in nano-bioscience. First, we look back on the history of SPM and introduce the application of AFM in this field. Next, we review surface force and single-molecule force measurements, which unveiled molecular processes at biointerfaces. Surface force measurements revealed the mechanism underlying the macroscopically observed protein and cell resistance of artificial monolayers and biomolecules. Meanwhile, single-molecule force spectroscopy has enabled researchers to explore the complex interaction of biomolecules from a microscopic viewpoint. These findings will contribute not only to the fundamental understanding of biomolecular processes but also to the design of new nano-biodevices.

Corresponding author: Tomohiro Hayashi


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Cite this article
Evan Angelo Quimada Mondarte, Hiroyuki Tahara, Kasinan Suthiwanich, Subin Song, Fan Wang, and Tomohiro Hayashi, Lab on a Tip: Atomic Force Microscopy as a Versatile Analytical Tool for Nano-bioscience, Sens. Mater., Vol. 33, No. 1, 2021, p. 223-232.



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