S&M Young Researcher Paper Award 2020
Recipients: Ding Jiao, Zao Ni, Jiachou Wang, and Xinxin Li [Winner's comments]
Paper: High Fill Factor Array of Piezoelectric Micromachined
Ultrasonic Transducers with Large Quality Factor

S&M Young Researcher Paper Award 2021
Award Criteria
Notice of retraction
Vol. 32, No. 8(2), S&M2292

Print: ISSN 0914-4935
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Sensors and Materials
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Glucose-driven Monolithic Polydimethylsiloxane Decompression Unit for Drug Release Device Using Plasma-activated Bonding Technology

Takahiro Arakawa, Koji Kurihara, Daisuke Mori, Toma Koji, Kazuyoshi Yano, and Kohji Mitsubayashi

(Received April 24, 2020; Accepted June 29, 2020)

Keywords: plasma-activated bonding, polydimethylsiloxane, enzyme membrane, decompression, glucose oxidase

A new enzymatic chemo-mechanical actuator that can convert the chemical energy of glucose into mechanical energy for an autonomous drug release system without electrical power was developed and demonstrated. The glucose- oxidase-immobilized membrane recognized glucose and converted the chemical energy found in glucose to mechanical energy of actuation. The decompression unit of the system consisted of an enzyme co-immobilized dialysis membrane, an ultraviolet cross-linkable polymer of polyvinyl alcohol (PVA-SbQ), and polydimethylsiloxane (PDMS) microfluidic channels. According to the evaluation of the bonding condition between PVA-SbQ and PDMS, direct bonding with different polymer materials was realized without damage to the enzyme of glucose oxidase. The optimized plasma treatment conditions were a sweep rate of 400 mm/s and an applied electric power of 140 W. The decompression unit had an appropriate decompression rate (2.16 Pa/s) at the glucose concentration of the blood sugar level, which was achieved by increasing the enzyme membrane area per gas phase volume. The monolithic PDMS decompression unit is promising for the development of a chemo-mechanical device driven by human blood sugar for diabetes treatment in the future.

Corresponding author: Kohji Mitsubayashi

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