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Notice of retraction
Vol. 34, No. 8(3), S&M3042

Notice of retraction
Vol. 32, No. 8(2), S&M2292

Print: ISSN 0914-4935
Online: ISSN 2435-0869
Sensors and Materials
is an international peer-reviewed open access journal to provide a forum for researchers working in multidisciplinary fields of sensing technology.
Sensors and Materials
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Sensors and Materials, Volume 31, Number 2(1) (2019)
Copyright(C) MYU K.K.
pp. 311-318
S&M1772 Research Paper of Special Issue
https://doi.org/10.18494/SAM.2019.2094
Published: February 8, 2019

Development of Polycaprolactone Microspheres with Controllable and Uniform Particle Size by Uniform Design Experiment in Emulsion Progress [PDF]

Cheng-Tang Pan, Yeong-Maw Hwang, Yu-Min Lin, Song-Wei Zeng, Shao-Yu Wang, Shiao-Wei Kuo, Shin-Pon Ju, Shih-Shin Liang, Zong-Hsin Liu, and Chung-Kun Yen

(Received May 30, 2018; Accepted October 11, 2018)

Keywords: polycaprolactone, emulsification, uniform design experiment, spherical carrier

In this study, we propose a method of manufacturing spherical carriers with controllable and uniform particle size. Emulsification and a uniform design experiment were carried out to obtain the optimal fabrication process. The results show that a stable emulsification of oil in water (O/W) was achieved with an ~18.18 wt% polycaprolactone (PCL) oil solution and an ~13.02 wt% polyvinyl alcohol (PVA) aqueous solution. Finally, the uniformity of the PCL microcarriers was ~87.9% with a particle size range of 10−20 μm. In the future, medical carriers will be loaded with different officially approved medicines. The carriers could improve the bioavailability of pharmaceutical products, extend the duration of their effectivity due to drug and minimize their side effects.

Corresponding author: Chung-Kun Yen


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Cite this article
Cheng-Tang Pan, Yeong-Maw Hwang, Yu-Min Lin, Song-Wei Zeng, Shao-Yu Wang, Shiao-Wei Kuo, Shin-Pon Ju, Shih-Shin Liang, Zong-Hsin Liu, and Chung-Kun Yen, Development of Polycaprolactone Microspheres with Controllable and Uniform Particle Size by Uniform Design Experiment in Emulsion Progress, Sens. Mater., Vol. 31, No. 2, 2019, p. 311-318.



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